Hi. Second thread here, first was about Wellbutrin which sadly did nothing for me. Now my new doc prescribed Effexor 75mg and Valdoxan to help with my circadian rhythm (I can never fall asleep before 4a.m. no matter how tired I am or how early I have to be up) because he says it might be a contribution to my depression - I obviously have to agree. Valdoxan works in the melatonin receptors. I have just started today and I've yet to take the Valdoxan - after dinner, but it sounds like an interesting combo. I think it isn't prescribed in the US due to possible liver damage so most of you probably haven't even heard of it, but if someone has done this and could share their experience I would be very thankful. I'm really curious about this.