Since hydrocodone is a prodrug and boken down in the colon before being metabolized by the CYP450 isoenzimes in the liver, could severe constipation decrease the amount of hydrocodone into the body? It would appear that when my constipation is worse, the less effective the hydrocodone becomes.
One of my major constipation problems is self-induced stress, severe anxiety, and MDD(major depressive disorder). And the hydrocodone sure doesn't help the constipation any!