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Generic >>. brand name
  1. #1
    ajax95 is offline New Member
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    Default Generic >>. brand name

    I have been taking Zoloft for awhile now. Recently Zoloft was replaced with Sertraline same dosage.

    After taking the generic brand for a week or so I was back to being severely depressed.

    I stopped generic and shortly thereafter was back to normal.

    Was this all in my head? or is the generic not the same?
    Last edited by Anonymous; 04-13-2007 at 06:14 PM. Reason: spelling

  2. #2
    VTRPh is offline New Member
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    Default

    I'm pretty sure the FDA allows a 10% discrepancy in testing standards for purity, dissolution rates, dose consistency, etc when comparing brand to generic. So the generic (sertraline) may have been off enough that your body noticed. Or it might be in your head.

  3. #3
    jonykanna is offline New Member
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    Default researh topics of clinical pharmacy with full text

    research topics

  4. #4
    jacobs8 is offline New Member
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    Default

    Generics might differ, if it feels that way you should consult with your doctor.

  5. #5
    exrph is offline New Member
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    Default generic

    1) CHECK FOR RATING SHOULD BE AB RATED
    2) CHECK MANUFACTOR
    3) sometimes the fillers are different and will result in different dissoultions
    rates, and with a drug like zoloft where blood levels are required to reach
    a therapuetic effect, this could throw off the level causing a non-therapuetic
    response.
    3) if the generic manufactor and the brand manufactor are the same.
    then the dissolutions rates should be the same, and the therapuetic
    response should be the same,

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